Concepedia

Mutation of <i>PA4292</i> in Pseudomonas aeruginosa Increases β-Lactam Resistance through Upregulating Pyocyanin Production

Xinrui Zhao, Yongxin Jin, Fang Bai, Zhihui Cheng, Weihui Wu, Xiaolei Pan

Antimicrobial Agents and Chemotherapy · 2022 · 11 citations · 28 references

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Concepts

Abstract

Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa is increasingly reported worldwide and usually causes infections with high mortality rates. Aztreonam/avibactam is a β-lactam/β-lactamase inhibitor (BLBLI) combination that is under clinical trials.

References

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Enhanced annotations and features for comparing thousands of<i>Pseudomonas</i>genomes in the Pseudomonas genome database

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An ordered, nonredundant library of <i>Pseudomonas aeruginosa</i> strain PA14 transposon insertion mutants

Nicole T. Liberati, Jonathan M. Urbach, Sachiko Miyata et al. · Proceedings of the National Academy of Sciences · 2006 · 992 citations · Full text

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