mBio · 2022 · 10 citations · 43 references
Life SciencesBiochemistryMicrobiologyEnzymologyMetabolismMicrobial MetabolismAmino Acid MetabolismEnzyme InhibitionReactive Metabolite FormationSulfur MetabolismCysteine DegradationCysteine MetabolismCysteine OxidationCysteine-related Sulfur CompoundsEnzymatic Redox ReactionsReactive Metabolite Mitigation
2-aminoacrylate (2AA) is a reactive metabolite formed as an intermediate in various enzymatic reactions. In the absence of RidA, this metabolite can persist in vivo where it attacks and inactivates specific PLP-dependent enzymes, causing metabolic defects and organism-specific phenotypes.
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