Cell Reports · 2022 · 107 citations · 53 references
Life SciencesImmunologyMolecular BiologyImmunotherapyInnate ImmunitySignal TransductionAntiviral ImmunityCytokine BiologyInflammatory SignalingInnate Immune ResponseInnate Immune Signaling PathwaysInterferon ResponsesAntiviral Innate SignalingAntiviral Interferon ResponsesInnate Immune EffectorsInterferon ProductionInterferon-stimulated GenesSting PathwayType I Interferon PathwaysType I Interferon Responses
and sodium butyrate promote host immunity by enhancing endogenous LL-37 expression and its mediated cGAMP immune response. Collectively, our data uncover an essential role of LL-37 in innate immune activation and suggest new strategies for immunotherapy.
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