Concepedia

Publication | Open Access

Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein

DOIFull Paper Access

25

Citations

56

References

2022

Year

Lingbing Zhang, Yandan Zhang, Xia Qin, Xuejun Jiang, Jun Zhang, Lejiao Mao, Ziqi Jiang, Yu Jiang, Gang Liu, Jingfu Qiu,
Critical Care

Abstract

This study is the first to prove that rACE2 plays a protective role against SARS-CoV-2 spike RBD protein-aggravated LPS-induced ALI in an animal model and illustrate the mechanism by which the ACE2-AngII-AT<sub>1</sub>R-NOX1/2 axis might contribute to SARS-CoV-2-induced ALI.

References

YearCitations

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