A compound Schiff base coating on biomedical magnesium alloy for enhanced corrosion resistance and biocompatibility

Abstract

The rapid degradation and delayed endothelialization of magnesium (Mg) alloys are the bottlenecks that limit their application in the direction of cardiovascular stents. In the previous work, we have reported a novel compound coating composed of three newly synthesized Schiff bases which significantly improved the corrosion resistance of the Mg alloy. However, the effect of electrostatic spraying time on the physicochemical properties, corrosion resistance and biocompatibility of the compound coating has not been systematically explored. In the present study, the compound Schiff base coating was electrostatic-sprayed on to the Mg alloy surface with 1.0 ​min (CP-1.0), 1.5 ​min (CP-1.5), 2.0 ​min (CP-2.0) and 2.5 ​min (CP-2.5), respectively. Our data suggested that CP-1.5 possessed more homogeneous surface, better corrosion resistance, stronger hemocompatibility and pro-endothelialization ability. Our study may give inspiration for designing the special coatings only for the biodegradable Mg alloy stents for vascular application.