Concepedia

Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer

Yao Xiao, Wenxia Yao, Mingzhen Lin, Wei Huang, Ben Li, Bin Peng, Qinhai Ma, Xinke Zhou, Min Liang

Drug Delivery · 2022 · 51 citations · 35 references

DOIFull text

Open access

Concepts

Abstract

Our findings validate that the successful design of PLGA@Icaritin, which can effectively active ICD and facilitate tumor recruitment in GC through inducing mitoDNA oxidative damage.

References

35

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2021 · 112.5K citations · Full text

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Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Claudia Allemani, Tomohiro Matsuda, V Di Carlo et al. · The Lancet · 2018 · 6.2K citations · Full text

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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Junwei Hou, Rongce Zhao, Weiya Xia et al. · Nature Cell Biology · 2020 · 1K citations · Full text

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Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

Chao Chen, Xiang Ni, Shaorui Jia et al. · Advanced Materials · 2019 · 504 citations

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Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

Zhuo Yu, Jianfeng Guo, Mengying Hu et al. · ACS Nano · 2020 · 428 citations

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