Crosstalk between IL‐15Rα ⁺ tumor‐associated macrophages and breast cancer cells reduces CD8 ⁺ T cell recruitment

Abstract

The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumor microenvironment of breast cancer. Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy.