Advanced Materials · 2022 · 16 citations · 0 references
Natural SciencesMaterials EngineeringMaterials ScienceBiomaterialsDrug DeliveryOcular Drug DeliveryCorneal Drug DeliveryCorneal Tissue EngineeringNanomaterials For Drug DeliveryNanomedicineNanostructured BiomaterialsScaffold DesignCorneal BiomaterialsCorneal Epithelium EngineeringCorneal ScaffoldsNanomaterials For Ocular ApplicationsOcular Drug Delivery BiomaterialsOcular Tissue Engineering ScaffoldsRegenerative NanomedicineTheranostic Nanomedicine
Corneal Cross-Linking ln article number 2109865, Rongrong Gao, Jinhai Huang, Xingtao Zhou, and co-workers report novel engineering of hydrangea-like RF@ZIF-8 microsphere composites with outstanding trans-epithelial corneal cross-linking (TE-CXL) efficacy, suggesting a promising nanomedicine strategy. The described use of the metal–organic framework as carrier to transfer hydrophilic negatively charged Riboflavin-5-phosphate (RF) molecules to the hydrophobic corneal epithelium, with excellent TE-CXL efficacy, may open up a new field of CXL.