Exercise intervention prevents early aged hypertension-caused cardiac dysfunction through inhibition of cardiac fibrosis

Abstract

Exercise training suppresses early aged hypertensive heart-induced LOX-2/TGF-β-mediated fibrotic pathways associated with decreasing AT₁R and FGF23, which might provide a new therapeutic effect for exercise training to prevent adverse cardiac fibrosis and myocardial abnormalities in early aged hypertension.