Enhanced Brain Delivery via Intranasal Administration of CarbamazepineLoaded Solid Lipid Nanoparticles: Optimization, Pharmacokinetic Analysis,In-vitro, and In-vivo Drug Release Study

Abstract

The study revealed that a high amount of drug was reached into the brain through intranasal administration compared to the intravenous route. Therefore, it can minimize the unwanted side effects of the Cbz associated with oral administration. The formulation SN1 possesses an excellent drug targeting efficiency of 3.014. Finally, the current experimental work concluded that there is a direct pathway from the intranasal route to the brain. This delivery system can be beneficial for directly delivering CNS-active drugs into the brain.