Theragnostic 64Cu/67Cu Radioisotopes Production With RFT-30 Cyclotron

Abstract

⁶⁴Cu and ⁶⁷Cu are theragnostic pair radionuclides with promising application in the nuclear medicine. ⁶⁴Cu is PET nuclide for the non-invasive diagnosis and ⁶⁷Cu is beta emitter for therapy of various cancers. This study discusses optimization efforts in the production of these radioactive coppers carried out with 30 MeV cyclotron. Optimized conditions include target preparation, chemical separation, and quality control. The production routes of ⁶⁴Cu and ⁶⁷Cu were studied based on the nuclear reactions of ⁶⁴Ni(p,n)⁶⁴Cu and ⁷⁰Zn(p,α)⁶⁷Cu. The produced ⁶⁴Cu and ⁶⁷Cu have >99.9% of the radionuclidic purity. The yield at the end of bombardment (EOB) of ⁶⁴Cu and ⁶⁷Cu is 28.5 MBq/μAh and ⁶⁷Cu is 0.58 MBq/μAh, respectively.