Production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair

Abstract

The production of ²⁰³Pb and ²¹²Pb was established using TRIUMF 13 MeV and 500 MeV cyclotrons, respectively. Both production methods provided radiometals suitable for subsequent radiolabeling reactions using known and novel chelates. Furthermore, the novel chelate DOTA-3Py may be a good candidate for biomolecule conjugation and further theranostic ²¹²Pb/²⁰³Pb studies.