The Relationship between Blood Levels and Dose of Methylmercury in Man

Abstract

The kinetics of blood deposition and clearance of methyl mercury were measured in volunteers given a single meal of fish containing 18 to 22/zg mercury/kg body weight. Peak blood concentrations were achieved within 4 to 14 hr. Disappearance from blood was biphasic, with average half-times of 7.6 hr and 52 days, respectively. The fraction of the dose deposited in the blood volume after completion of tissue distribution was 5.9%. Blood concentrations of total mercury reached as high as 60 ng mercury/ml, whereas inorganic mercury did not exceed 2 ng mercury/ml. The average red blood cell to plasma concentration ratio was 21 and the hair to blood ratio was 292. The kinetic parameters relating to blood deposition and clearance were used to calculate the expected relationship between average long-term daily intake of methyl mercury and steady state blood concentration.