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Absolute configuration of allosamizoline, an aminocyclitol derivative of the chitinase inhibitor allosamidin.
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1988
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Bioorganic ChemistryEngineeringGlycobiologyOrganic ChemistryChemical DerivativeAminocyclitol DerivativeChitinase Inhibitor AllosamidinConstituent Aminocyclitol DerivativeInhibitory ActivityAbsolute ConfigurationBiochemistryExciton Chirality MethodDrug DevelopmentPharmacologyMolecular ModelingBiomolecular EngineeringMedicineDerivative (Chemistry)Drug Discovery
The absolute configuration of allosamizoline (1), a constituent aminocyclitol derivative of allosamidin (2), was elucidated by the exciton chirality method using its 3, 4-bis[p-(dimethylamino)benzoyl]-6-trityl derivative (7).