Finding the lowest free energy conformation of a protein is an NP-hard problem: Proof and implications

The protein data bank: A computer-based archival file for macromolecular structures

F. C. Bernstein, Thomas F. Koetzle, G. J. B. Williams et al. · Journal of Molecular Biology · 1977 · 8.6K citations

Life Sciences, Biochemistry, Bioinformatics +14

Principles that Govern the Folding of Protein Chains

Christian B. Anfinsen · Science · 1973 · 7.1K citations

Life Sciences, Biochemistry, Biophysics +17

Some simplified NP-complete graph problems

M. R. Garey, David S. Johnson, Larry Stockmeyer · Theoretical Computer Science · 1976 · 2.1K citations

Computing, Computer Science, Mathematics +11

THE KINETICS OF FORMATION OF NATIVE RIBONUCLEASE DURING OXIDATION OF THE REDUCED POLYPEPTIDE CHAIN

Christian B. Anfinsen, E Haber, Michael Sela et al. · Proceedings of the National Academy of Sciences · 1961 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

Alexander Wlodawer, Maria Miller, Mariusz Jaskólski et al. · Science · 1989 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +17