Organomediated Enantioselective ¹⁸F Fluorination for PET Applications

Abstract

Abstract The first organomediated asymmetric 18 F fluorination has been accomplished using a chiral imidazolidinone and [ 18 F]N‐fluorobenzenesulfonimide. The method provides access to enantioenriched 18 F‐labeled α‐fluoroaldehydes (>90 % ee ), which are versatile chiral 18 F synthons for the synthesis of radiotracers. The utility of this process is demonstrated with the synthesis of the PET (positron emission tomography) tracer (2 S ,4 S )‐4‐[ 18 F]fluoroglutamic acid.