Molecular Imaging of Cancer Cells Using a Bacteriophage‐Based ¹²⁹Xe NMR Biosensor

Abstract

NMR-Bildgebung: Der fadenförmige Bakteriophage fd, der Antikörper exprimiert und den epidermalen Wachstumsfaktor-Rezeptor (EGFR) erkennt, wurde mit käfigartigen Xenon-bindenden Molekülen (CryA) modifiziert. Das resultierende Kontrastmittel bindet an EGFR-positive Zelllinien und wurde mit einer Kombination aus hyperpolarisierter 129Xe-NMR-Spektroskopie und CEST (hyperCEST, siehe Bild) detektiert. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.