Cryofibrinogenemia

Abstract

THERE is recent evidence that the clinical paradox of a hemorrhagic diathesis simultaneously associated with intravascular thromboses can be accompanied by the development of qualitative changes in plasma proteins. Occasionally, such a bleeding tendency accompanied by intravascular thromboses has been attributed to a cryoglobulin.2 , 3 The prefix "cryo" designates a protein moiety that will precipitate in the cold but will redissolve when warmed. In 1955 Korst and Kratochvil4 reported another abnormal plasma protein that was associated with intravascular thromboses. This protein was clottable and had many other physical and chemical properties similar to fibrinogen, and it also exhibited the property of . . .