Chemical Communications · 2018 · 35 citations · 24 references
Life SciencesBiochemistryImmunologyAntibody EngineeringGlycobiologyMonoclonal AntibodiesGlycan RemodelingGlycan StructureGlycan-protein InteractionsGlycoengineering Of AntibodiesGlycosylation PathwaysProtein GlycosylationAntibody Glycan RecognitionAntibody Glycosylation ControlAntibody Glycosylation EffectsGlycan Analysis Of AntibodiesGlycan-binding SpecificityGlycoengineering Of Monoclonal AntibodiesReceptor Glycan Specificity
The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specificity.
24