Susceptibility of biofilm cells of<i>Pseudomonas aeruginosa</i>to bactericidal actions of whole blood and serum

Abstract

The planktonic and young biofilm cells (harvested on day 2) of mucoid Pseudomonas aeruginosa were susceptible to the bactericidal actions of whole blood and serum. Aging biofilms of this organism (harvested on day 7) were very resistant to the killing effect of whole blood and serum. From this study we propose that the establishment of aging biofilms may contribute to persistence of this organism in biofilm-associated infections.