Effect of <scp>GLP</scp> ‐1 receptor agonist treatment on body weight in obese antipsychotic‐treated patients with schizophrenia: <scp>a</scp> randomized, placebo‐controlled trial

Abstract

Treatment with exenatide once-weekly did not promote weight loss in obese, antipsychotic-treated patients with schizophrenia compared to placebo. Our results could suggest that the body weight-lowering effect of GLP-1RAs involves dopaminergic signaling, but blockade of other receptor systems may also play a role. Nevertheless, anti-obesity regimens effective in the general population may not be readily implemented in antipsychotic-treated patients with schizophrenia.