Chemical and Pharmaceutical Bulletin · 1962 · 25 citations · 0 references
MedicineBiochemistryPharmacologyBiochemical PharmacologyDrug MetabolismPharmaceutical ToxicologyDrug DispositionMetabolite IdentificationRabbit PharmacologyDrug Metabolism In RabbitsHydroxybenzoic AcidsMetabolite PharmacokineticsPaper ChromatographyVeterinary Pharmacokinetics
The ether-type glucuronide of p-hydroxybenzoic acid was isolated from the urine of rabbits receiving methyl p-hydroxybenzoate and its structure was established as p-carboxyphenyl-β-D-glucopyranosiduronic acid. Three main metabolites, p-hydroxybenzoic acid, p-hydroxyhippuric acid, and the ether-type glucuronide, were identified in the urine, and the ester-type glucuronide and p-carboxyphenyl sulfate were proved as minor metabolites by means of paper chromatography.