Journal of the National Comprehensive Cancer Network · 2016 · 300 citations · 149 references
MedicineOncologySurgeryOncologic SurgerySurgical OncologyTumor PathologyGastrointestinal Stromal TumorsMalignant NeoplasmsMalignant TumorsMesenchymal TumorsSoft Tissue SarcomasTumor ClassificationDesmoid Tumor TherapyMalignant Soft Tissue TumorsMultidisciplinary Team ManagementMultidisciplinary Team ReviewNeck SarcomasSarcoma PathologySoft Tissue Sarcoma HistopathologySoft Tissue Sarcoma Treatment
Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for Soft Tissue Sarcoma (available at NCCN.org) provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumor, desmoid tumors, and rhabdomyosarcoma. This manuscript discusses guiding principles for the diagnosis and staging of STS and evidence for treatment modalities that include surgery, radiation, chemoradiation, chemotherapy, and targeted therapy.
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James R. Egner · JAMA · 2010 · 6.1K citations
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
David Malkin, Frederick P. Li, Louise C. Strong et al. · Science · 1990 · 3.8K citations
Life Sciences, Genetics, Oncology +17