Synthesis and Antiviral Activity of Alkyl P, P-Bis(1-aziridinyl)phosphinate

Abstract

It has been found that several compounds of N-alkyl-P, P-bis(1-aziridinyl)phosphinic amide series have in vitro antiviral activity and, therefore, 12 compounds of Alkyl P, P-bis(1-aziridinyl)phosphinate series were prepared and their in vitro activity tested against the Nakayama strain of Japanese B encephalitis virus. N-Decyl, N-undecyl, and N-dodecyl derivatives were found to be effective against this virus.