Review of Scopoletin: Isolation, Analysis Process, and Pharmacological Activity

Abstract

Scopoletin (7-hydroxy-6-methoxy coumarin) is a coumarin phenolic compound widely found in plants and includes coumarin derivatives that are superior in several types of plants. This article was created to provide information regarding the isolation process, analysis, and pharmacological activity. The method used is to study and analyze scopoletin articles from national and international journals. From the data sources studied, the yield of scopoletin extract in Morinda citrifolia L was 0.93%, Helichrysum italicum was 1.933mg / 100g. The scopoletin content in Convolvulus pluricaulis is 0.1738%, Artemisia annua is 0.3%, Lasianthus lucidus is 54 mg, and Morus alba L. (Po-sa) is 0.0009%. The highest yield of scopoletin extract was 0.93% found in noni (Morinda citrifolia L) using the Soxhlet method. The highest scopoletin content was 0.3% in Artemisia annua using column chromatography and recrystallization. Scopoletin identification can be done using Thin Layer Chromatography (TLC), High-Performance Liquid Chromatography (HPLC), Fourier Transform Infrared Spectrophotometer (FTIR), Nuclear Magnetic Resonance, and Mass Spectrometry. Based on in vitro studies, scopoletin has pharmacological activities, including as an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. Pharmacological activities that have been proven in vivo are antithyroid, antihypertensive, anti-proliferative, anti-inflammatory, neurological, anti-dopaminergic and anti-adrenergic, antidiabetic, and antihyperuricemic activities. From the various pharmacological activities of scopoletin, it has the potential to be further developed.