Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus. IV. Structure Elucidation of Pyripyropenes M to R.

Abstract

Six new pyripyropenes, M to R, were isolated from the ethyl acetate extracts of the jar fermentation broth of Aspergillus fumigatus FO-1289-2501. Structural elucidation indicated that all the pyripyropenes have the same pyridino-α-pyrone sesquiterpene core as pyripyropenes A to L. Among them pyripyropene M showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase activity with an IC50 value of 3.80μM in rat liver microsomes, but pyripyropenes N to R showed moderate inhibitory activity (IC50 11.0-78.0μM).