Copper‐Catalyzed γ‐Selective and Stereospecific Direct Allylic Alkylation of Terminal Alkynes: Synthesis of Skipped Enynes

Abstract

Nicht konjugiert: Die Titelreaktion überführt Alkine durch Einwirkung von internen sekundären Allylphosphaten hoch γ-regioselektiv und E-stereoselektiv in 1,4-Enine. Enantiomerenangereicherte Allylphosphate ergaben die 1,3-anti-konfigurierten chiralen 1,4-Enine, die verschiedentlich derivatisiert und in der formalen Totalsynthese eines GnRH-Antagonisten eingesetzt wurden. phen=1,10-Phenanthrolin. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.