Stereodivergent Total Synthesis of Δ⁹‐Tetrahydrocannabinols

Abstract

Abstract All four stereoisomers of Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.