Concepedia

Publication | Open Access

Re-trafficking of hERG reverses long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes

DOIFull Paper Access

108

Citations

22

References

2014

Year

Ashish Mehta, Glen Lester Sequiera, Chrishan J. A. Ramachandra, Yuliansa Sudibyo, Yingying Chung, Jingwei Sheng, Keng Yean Wong, Teng Hong Tan, Philip Wong, Reginald Liew,
Cardiovascular Research

Abstract

Our in vitro study shows an alternative approach to rescue diseased LQTS2 phenotype via corrective re-trafficking therapy using a small chemical molecule, such as ALLN. This potentially novel approach may have ramifications in other clinically relevant trafficking disorders.

References

YearCitations

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