New bitter C27 and C30 terpenoids from the fungus Ganoderma lucidum (Reishi).

Abstract

Four new bitter terpenoids, lucidenic acids A (1), B (2), C (3) and ganoderic acid C (5), were isolated from the fruiting bodies of Ganoderma lucidum, together with the known bitter ganoderic acid B (4). On the basis of spectroscopic data and chemical conversion, their structures were determined to be 7β-hydroxy-4, 4, 14α-trimethyl-3, 11, 15-trioxo-5α-chol-8-en-24-oic acid, 7β, 12β-dihydroxy-4, 4, 14α-trimethyl-3, 11, 15-trioxo-5α-chol-8-en-24-oic acid, 3β, 7β, 12β-trihydroxy-4, 4, 14α-trimethyl-11, 15-dioxo-5α-chol-8-en-24-oic acid and 7β-hydroxy-3, 11, 15, 23-tetraoxo-5α-lanost8-en-26-oic acid, respectively.