Neurocase · 1999 · 56 citations · 34 references
Life SciencesNeurologyNeuroscienceBehavioral NeuroscienceCognitive NeuroscienceNeuropsychologyBrain-behavior RelationshipsCognitive ImpairmentFrontal Lobe FunctionsFrontal Lobe SyndromesNeurocognitive DisordersNeuropsychiatric DisordersFrontal Lobe LesionsNeurobehavioral AlterationsNeurobehavioral DisordersNeurobehavioral SyndromesNeurocognitive ProfileProblem-solving DeficitsSocial Cognition DeficitsSocial Cognition Impairment
Abstract We describe a 50-year-old male patient (MGS) with a right frontal ventromedial lesion who showed preserved general cognitive, abstract thinking and problem-solving abilities, in contrast to gross impairment in his social competence, social decision making and social conduct. MGS also demonstrated diminished sensitivity to socially relevant stimuli and situational nuances, impairment in sexual behavior, lost sense of responsibility, and disinhibition. We interpret his neurobehavioral profile, identical to the one of the famous 19th century patient Phineas Gage, in the light of the hypothesis that emotion and social conduct regulation depend on the ventromedial frontal cortex.
34
Insensitivity to future consequences following damage to human prefrontal cortex
Antoine Bechara, António R. Damásio, Hanna Damásio et al. · Cognition · 1994 · 6.1K citations
Judith P. Frankmann, Jeff Adams · The American Journal of Psychology · 1904 · 4.3K citations