Base-induced side reactions in Fmoc-solid phase peptide synthesis:Minimization by use of piperazine as Nα-deprotectionreagent

The 9-fluorenylmethyloxycarbonyl family of base-sensitive amino-protecting groups

Louis A. Carpino · Accounts of Chemical Research · 1987 · 184 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis

Janelle Lauer, Cynthia G. Fields, Gregg B. Fields · Letters in Peptide Science · 1995 · 153 citations

Pharmacy, Biochemistry, Drug Discovery +6

Diketopiperazine formation in solid phase peptide synthesis using p-alkoxybenzyl ester resins and Fmoc-amino acids

Enrique Pedroso, Anna Grandas, F. Xavier de las Heras et al. · Tetrahedron Letters · 1986 · 137 citations

Pharmacy, Medicinal Chemistry, Organic Chemistry +10

Formation of aspartimide peptides in Asp-Gly sequences

Ernesto Nicolás, Enrique Pedroso, Ernest Girald · Tetrahedron Letters · 1989 · 117 citations

Life Sciences, Biochemistry, Molecular Biology +5

Removal of 9-fluorenylmethyloxycarbonyl (Fmoc) group with tetrabutylammonium fluoride

Masaaki Ueki, Masahide Amemiya · Tetrahedron Letters · 1987 · 106 citations

Natural Sciences, Chemical Engineering, Chemistry +3