Journal of Clinical Investigation · 2003 · 509 citations · 59 references
Veterinary MedicinePharmacotherapyTranslational SciencesInflammationSepsisTranslational MedicineComplications Of SepsisSepsis DiagnosisSepsis ManagementSepsis PathophysiologySepsis PharmacotherapySeptic ShockSepsis PathologySepsis-associated Inflammation
Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.
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Intensive Insulin Therapy in Critically Ill Patients
Greet Van den Berghe, Pieter Wouters, Frank Weekers et al. · New England Journal of Medicine · 2001 · 10K citations · Full text