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Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation
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2020
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Chemoprevention StrategyPathologyAdvanced Colorectal CancerCancer BiologyTumor BiologyGastrointestinal OncologyNfat2 Nuclear TranslocationCancer Cell BiologyCalcium Channel BlockerImmune EscapeMolecular OncologyCancer ResearchMedicineColorectal CancerCancer TreatmentPharmacologyCell BiologyTumor MicroenvironmentNife TreatmentImmune Checkpoint InhibitorOncology
(Cell Reports 33, 108327–1–108327–13, e1–e4; October 27, 2020) In the originally published version of this article, the legend of Figure 6F incorrectly described the image. NIFE treatment did not counteract the effect of coculture with SW620, and in fact, demonstrated similar results. This has now been corrected online. The authors regret this error. Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear TranslocationWu et al.Cell ReportsOctober 27, 2020In BriefWu et al. provide evidence that nifedipine, a calcium channel blocker, has utility in the treatment of advanced colorectal cancer (CRC) by affecting the tumor itself and anti-tumor immunity. Full-Text PDF Open Access