Concepedia

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase

Christina Tysoe, S. Caner, Matthew B. Calvert, Anna L. Win‐Mason, Gary D. Brayer, Stephen G. Withers

Chemical Science · 2019 · 18 citations · 14 references

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Abstract

Simplified analogues of montbretin A bind similarly to human alpha amylase and with nanomolar affinity.

References

14

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation

K. G. M. M. Alberti, Paul Zimmet · Diabetic Medicine · 1998 · 15.3K citations

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Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids

Kenjiro Tadera, Yuji Minami, Kouta TAKAMATSU et al. · Journal of Nutritional Science and Vitaminology · 2006 · 1K citations · Full text

, , +11

Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-Amylase

Elena Lo Piparo, Holger Scheib, Nathalie Frei et al. · Journal of Medicinal Chemistry · 2008 · 462 citations · Full text

, , +17

The structure of human pancreatic<i>α</i>-amylase at 1.8 Å resolution and comparisons with related enzymes

Gary D. Brayer, Yaoguang Luo, Stephen G. Withers · Protein Science · 1995 · 399 citations · Full text

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Subsite Mapping of the Human Pancreatic α-Amylase Active Site through Structural, Kinetic, and Mutagenesis Techniques<sup>,</sup>

Gary D. Brayer, Gary Sidhu, R. Maurus et al. · Biochemistry · 2000 · 261 citations

, , +17