Canadian Journal of Biochemistry and Physiology · 1963 · 34 citations · 9 references
Life SciencesBiochemistryImmunologyCellular MetabolismMetabolismRedox BiochemistryNadh MetabolismNadph MetabolismOxidative MetabolismOxidative StressReactive Oxygen SpeciesRedox SignalingHydrogen Peroxide GenerationImmune Cell Nadph MetabolismNadh OxidationNadph ConsumptionNadph Oxidase ActivityNadph OxidasesNadph UtilizationNadph-dependent Enzymes
A homogenate of guinea pig polymorphonuclear leucocytes contains an enzyme system capable of oxidizing, in presence of oxygen, NADPH and NADH with the formation of hydrogen peroxide. The enzyme is much more active towards NADPH than to NADH. The presence of manganese ions strongly enhances the oxidase activity. It is suggested that the release of the NADPH oxidase in the leucocytes, during phagocytosis, accounts for the stimulation of the hexose monophosphate pathway that occurs in phagocytosis.
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The Biochemical Basis of Phagocytosis
Anthony J. Sbarra, Manfred L. Karnovsky · Journal of Biological Chemistry · 1959 · 1.2K citations · Full text
Biochemical Aspects of Phagocytosis
G. Y. N. Iyer, Muhammad Fajar Islam, J. H. Quastel · Nature · 1961 · 659 citations