Percutaneous Absorption and Besidual Amount on Skin Surface of Zinc bis (2-pyridylthio)-1, 1'-dioxide.

Abstract

Distribution after peroral injection, percutaneous absorption and residual amount on skin surface of zinc bis (2-pyridylthio)-1, 1'-dioxide (Zinc Omadine) labelled with 35S and 65Zn were observed. Following the peroral injection, this compound was decomposed in stomach. 65Zn-compound was excreted mainly in feces and 35S compound in urine. Percutaneous absorption of Zinc Omadine following the application of shampoo, ointment and water suspension containing the compound to skin was very slow and little. Residual amount on skin surface after application of the preparations was less than 1% of the amount of Zinc Omadine applied.