Concepedia

Fomitellic Acids, Triterpenoid Inhibitors of Eukaryotic DNA Polymerases from a Basidiomycete, <i>Fomitella</i> <i>fraxinea</i>

Nobukazu Tanaka, Akitoshi Kitamura, Yoshiyuki Mizushina, Fumio Sugawara, Kengo Sakaguchi

Journal of Natural Products · 1998 · 60 citations · 5 references

DOI

Concepts

Abstract

Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.

References

5

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Screening of Inhibitor of Eukaryotic DNA Polymerases Produced by Microorganisms.

Yoshiyuki Mizushina, H. Yagi, Nobukazu Tanaka et al. · The Journal of Antibiotics · 1996 · 47 citations · Full text

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A meiotic DNA polymerase from Coprinus cinereus: further purification and characterization

Shimako Matsuda, Kiyoshi Takami, Akira Sono et al. · Chromosoma · 1993 · 31 citations

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