The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′, 3′-dideoxynucleosides inhibit DNA polymerase γ by different mechanisms

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

Marinos C. Dalakas, Isabel Illa, G. Pezeshkpour et al. · New England Journal of Medicine · 1990 · 848 citations · Full text

Medicine, Infectious Diseases, Pathology +13

Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity.

Ching‐Hsein Chen, M A Vázquez-Padua, Y C Cheng · Molecular Pharmacology · 1991 · 295 citations

Life Sciences, Biochemistry, Pharmacology +13

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

M H St Clair, C A Richards, T Spector et al. · Antimicrobial Agents and Chemotherapy · 1987 · 280 citations · Full text

Life Sciences, Molecular Biology, Enzymology +11

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

Jan Balzarini, Gil-Jong Kang, Maha Dalal et al. · Molecular Pharmacology · 1987 · 234 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.

Ying‐Chih Cheng, Ginger E. Dutschman, Kenneth F. Bastow et al. · Journal of Biological Chemistry · 1987 · 227 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15