Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 2012 · 49 citations · 0 references
ComputingComputer SciencePathologyComputer VisionHistopathologyMachine LearningCancer DetectionComputer-aided DiagnosisMedical Image AnalysisMedical ImagingSupport Vector MachinesTumor DetectionBreast Cancer HistopathologyDigital Pathology AnalysisHistopathological InterpretationHistopathology Image AnalysisImage-based Diagnostic FeaturesMorphometric AnalysisPathology Image AnalysisSupport Vector Machine Classification
Detection of malignancy from histopathological images of breast cancer is a labor-intensive and error-prone process. To streamline this process, we present an efficient Computer Aided Diagnostic system that can differentiate between cancerous and non-cancerous H&E (hemotoxylin&eosin) biopsy samples. Our system uses novel textural, topological and morphometric features taking advantage of the special patterns of the nuclei cells in breast cancer histopathological images. We use a Support Vector Machine classifier on these features to diagnose malignancy. In conjunction with the maximum relevance - minimum redundancy feature selection technique, we obtain high sensitivity and specificity. We have also investigated the effect of image compression on classification performance.