Canadian Medical Association Journal · 2009 · 416 citations · 9 references
Public HealthBiostatisticsEvidence-based PracticeExperimental DesignClinical Trial DesignClinical TrialsEfficacy EvaluationRandomized Comparative TrialsRandomized Controlled TrialsStudy DesignExplanatory Clinical TrialsPragmatic Trial DesignRandomized Clinical TrialsTrial Methodology
Randomized trials have traditionally been broadly categorized as either an effectiveness trial or an efficacy trial, although we prefer the terms “pragmatic” and “explanatory.” Schwartz and Lellouch described these 2 approaches toward clinical trials in 1967. [1][1] These authors coined the
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Low-Dose Aspirin to Prevent Preeclampsia in Women at High Risk
Steve N. Caritis, Baha M. Sibai, John C. Hauth et al. · New England Journal of Medicine · 1998 · 670 citations · Full text