External validity of randomised controlled trials: “To whom do the results of this trial apply?”

Tissue Plasminogen Activator for Acute Ischemic Stroke

The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group · New England Journal of Medicine · 1995 · 11.7K citations

Medicine, Pharmacology, Pharmacotherapy +17

The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.

Sara H. Downs, Nicholas Black · Journal of Epidemiology & Community Health · 1998 · 8.3K citations · Full text

Medicine, Health Promotion, Health Assessment +16

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

The Lancet · 2002 · 7K citations

Medicine, Cardiology, Pharmacotherapy +13

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

Milton Packer, Michael R. Bristow, Jay N. Cohn et al. · New England Journal of Medicine · 1996 · 4.7K citations · Full text

Medicine, Cardiology, Pharmacology +11

Endarterectomy for Asymptomatic Carotid Artery Stenosis

Michael Walker · JAMA · 1995 · 4.4K citations

Medicine, Neurosurgery, Surgery +12