Four Novel Withanolide-Type Steroids from the Leaves of Solanum cilistum.

Abstract

Four novel withanolide-type steroids named cilistols p, pm, p1 and u (1—4, respectively), were isolated from the leaves of Solanum cilistum. The respective structures were characterized by spectroscopic means as follows: cilistol p (1) was (22R,24R,25R,26S)-1-oxo-22,26-epoxy-3α,5α-cycloergostane-6β,17α,24,25,26-pentaol 26-O-β-D-glucopyranoside, cilistol pm (2) corresponded to the 6-O-methyl ether derivative of 1; cilistol p1 (3) was represented as the 24-O-methyl ether of 1, and cilistol u (4) was shown to be the epoxide between C-24 and -25, presumably bearing cilistols p, pm and p1 by ring-opening.