Publication | Open Access
A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF<sub>2α</sub>, fluprostenol, and travoprost guided by biocatalytic retrosynthesis
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Citations
71
References
2021
Year
Medicinal ChemistryEngineeringBiochemistryBiocatalytic RetrosynthesisNatural SciencesUnified StrategyOrganic ChemistryStereoselective SynthesisChemistryPharmacologyAsymmetric CatalysisEnzymatic Redox TransformationsSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringChemoenzymatic Total SynthesisNatural Product Synthesis
We report a unified chemoenzymatic asymmetric synthesis of five prostaglandins, featuring two enzymatic redox transformations and a copper(<sc>ii</sc>)-catalyzed regioselective <italic>p</italic>-phenylbenzoylation.
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