Concepedia

A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF<sub>2α</sub>, fluprostenol, and travoprost guided by biocatalytic retrosynthesis

Kejie Zhu, Meifen Jiang, Baijun Ye, Guotai Zhang, Weijian Li, Pei Tang, Zedu Huang, Fen‐Er Chen

Chemical Science · 2021 · 35 citations · 71 references

DOIFull text

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Concepts

Abstract

We report a unified chemoenzymatic asymmetric synthesis of five prostaglandins, featuring two enzymatic redox transformations and a copper(<sc>ii</sc>)-catalyzed regioselective <italic>p</italic>-phenylbenzoylation.

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