Angewandte Chemie International Edition · 1999 · 19 citations · 0 references
PharmacyMedicinal ChemistryMicrobiologyCrop ProtectionLead OptimizationMycologyAntifungal AgentsAntifungal ResistanceFungal Secondary MetabolitesHit-to-lead OptimizationLead Compound DesignNatural Product Drug DiscoveryBotanical FungicidesFungicide ChemistryNatural Antifungal CompoundsNew Antifungal AgentsNovel Antifungal Drug DevelopmentOrganic FungicidesPlant-derived FungicidesStructure-based Lead Discovery
A fungus that grows on pinecones yields a compound with antifungal activity that has become the natural model for a significant innovation in crop protection. Variation and optimization of the lead structure of strobilurin A (1) and selection of derivatives which fulfill all practical requirements, for example, kresoxim-methyl (2), led to an exciting and pan-industrial competition for the development of the strobilurines as a new, highly active, and broadly applicable class of fungicides—a fascinating success story.