Life SciencesNeurologyNeuroscienceClinical NeuroscienceNeurochemistryNeuropharmacologyCerebrovascular DiseaseNeuroprotectionNeuroprotective PharmacologyStrokeStroke PharmacotherapyBlood FlowCerebral Blood Flow AlterationsCerebral Ischemia NeuroprotectionNeuroprotective AgentsNeuroprotective PharmacotherapyRodent Cerebral IschemiaStroke ModelsStroke Neuroprotection
Neuroprotective therapy for stroke remains unproven despite its ability to substantially reduce injury in animal stroke models. Based on an understanding of the cascade of biochemical events that follow interruption of blood flow to the brain, various neuroprotective drugs have been tested in clinical studies, but none have been shown to improve clinical outcome. Progress depends on designing our clinical trials to better simulate the experimental conditions under which these drugs have been found to be effective.