Biology of the Cell · 2004 · 14 citations · 0 references
MedicineMolecular BiologyPharmacologyCell SignalingMolecular PharmacologySignal TransductionLigand BindingReceptor BindingReceptor PharmacologyReceptor PhysiologyReceptor RegulationReceptor-ligand InteractionsAdrenergic Receptor SignalingAdrenergic SignalingAdrenergic TransmissionG Protein-coupled Receptor ActivationG Protein-coupled Receptor BindingG Protein-coupled Receptor RegulationG Protein-coupled Receptor Structure-function RelationshipsG-protein-coupled Receptors
Summry— The aim of a large number of studies on G protein‐coupled receptors was centered on understanding the structural basis of their main functional properties. Here, we will briefly review the results obtained on the α1‐adrenergic receptor subtypes belonging to the rhodopsin‐like family of receptors. These findings contribute, on the one hand, to further understand the molecular basis of adrenergic transmission and, on the other, to provide some generalities on the structure‐functional relationship of G protein‐coupled receptors.