Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto‐oxidation

Abstract

The aim of this study was to evaluate several plant extracts with a view to developing melanogenesis inhibitors. In this study, 100 plant extracts were screened to elucidate their whitening effects using in vitro inhibition of tyrosinase and DOPA auto‐oxidation activity. Several plant extracts such as Chaenomeles speciosa, Dryopteris crassirhizoma, Gastrodia ellata, Glycyrrhiza glabra, Morus alba, Myristica fragrans, Rheum palmatum and Sophora japonica showed inhibition of mushroom tyrosinase activity. Plant extracts including Bupleurum falcatum, Caragana sinica, Morus alba and Tussilago farfara showed inhibition of DOPA auto‐oxidation activity. L'objet de cette etude etait d'evaluer plusieurs extraits vegetaux dans le but de developper des inhibiteurs de la melanogenese. Dans cette etude, on a crible 100 extraits vegetaux pour connaitre leurs effets blanchissants en utilisant in vitro l'inhibition de la tyrosinase et de l'activite auto‐oxydante de la DOPA. Plusieurs extraits vegetaux tels que Chaenomeles speciosa, Dryopteris crassirhizoma, Gastrodia ellata, Glycyrrhiza glabra, Morus alba, Myristica fragrans, Rheum palmatum et Sophora japonica presentent une activite d'inhibition de la tyrosinase du champignon. Des extraits vegetaux comprenant Bupleurum falcatum, Caragana sinica, Morus alba et Tussilago farfara montrent une inhibition de l'activite d'auto‐oxydation de la DOPA.