Angewandte Chemie · 2014 · 93 citations · 42 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryChiral SeparationCoordination ChemistryHeterocyclic ChemistryEnantioselective CatalysisEnantioselective Synthesis
Abstract A simple, new type of chiral sulfinamide monophosphines, the so‐called Ming‐Phos ligands, is reported; these ligands could be easily prepared from inexpensive and commercially available starting materials. The Ming‐Phos ligands performed well in the enantioselective gold‐catalyzed cycloaddition reaction of 2‐(1‐alkynyl)‐alk‐2‐en‐1‐ones with nitrones. Both enantiomers of the products could be obtained in good yields and with excellent diastereo‐ and enantioselectivity through transformations that were catalyzed by gold complexes derived from two diastereomers of Ming‐Phos ligand M5 (Ar=1‐naphthyl).
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A Powerful Chiral Counterion Strategy for Asymmetric Transition Metal Catalysis
Gregory L. Hamilton, Eun Joo Kang, Miriam Mba et al. · Science · 2007 · 902 citations