Protein Chemical Synthesis by Ligation of Peptide Hydrazides

Abstract

Der pH-Wert bestimmt die Selektivität: Die Ligation von Peptidhydraziden ergänzt als neues Verfahren der chemischen Proteinsynthese die native chemische Ligation. Peptidhydrazid-Reagentien könnten sich als lange gesuchtes Äquivalent zu dem „Thioester-Synthon“ erweisen, das unter den Bedingungen der nativen chemischen Ligation beständig ist. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.